Parkinson’s disease and colorectal cancer risk—A nested case control study

Disentangling the Association between Statins, Cholesterol, and Colorectal Cancer: A Nested Case-Control Study

BACKGROUND Several prior studies have found an association between statin use and reduced risk of colorectal cancer. We hypothesized that these findings may be due to systematic bias and examined the independent association of colorectal cancer risk with statin use, serum cholesterol, and change in cholesterol concentration. METHODS AND FINDINGS 22,163 colorectal cancer cases and 86,538 match...

Original Contribution Plasma Enterolignan Concentrations and Colorectal Cancer Risk in a Nested Case-Control Study

Enterolignans are biphenolic compounds that possess several biologic activities whereby they may influence carcinogenesis. The authors investigated the association between plasma enterolactone and enterodiol and colorectal cancer risk in a Dutch prospective study. Among more than 35,000 participants aged 20–59 years, 160 colorectal cancer cases were diagnosed after 7.5 years of follow-up (1987–...

Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study

Epidemiological and experimental evidence suggest that vitamin D is protective against the risk of colorectal cancer. Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic variants in VDR and...

Colorectal cancer and folate status: a nested case-control study among male smokers.

Evidence is accumulating that folate, a B vitamin found in green leafy vegetables, may affect the development of neoplasia. We examined the relationship between folate status and colorectal cancer in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Study cohort of male smokers 50-69 years old. Serum folate was measured in 144 incident cases (91 colon, 53 rectum) and 276 con...

Case–Control Study, Nested